Relief

Kava

  • Singh YN, Kava: an overview. J Ethnopharmacol. Aug;37(1):13- 45.1992.
  • Savage KM, Stough CK, Byrne GJ, Scholey A, Bousman C, Murphy J, Macdonald P, Suo C, Hughes M, Thomas S, Teschke R, Xing C, Sarris J. Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial. Trials. 2015 Nov 2;16:493.
  • Pittler M, Ernst E.Kava extract for treating anxiety.Cochrane Database Syst Rev. 2002;(2):CD003383.
  • Olsen LR, Grillo MP, Skonberg C. Constituents in kava extracts potentially involved in hepatotoxicity: a review. Chem Res Toxicol. Jul 18;24(7):992-1002,2011
  • Ligresti A, Villano R, Allarà M, Ujváry I, Di Marzo V. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB1 receptor ligand. Pharmacol Res.Aug;66(2):163-9. 2012.
  • Coulter D. Assessment of the risk of hepatotoxicity with kava products. WHO appointed committee. Geneva: World Health Organization; 2007.
  • Kuchta K et al. German Kava Ban Lifted by Court: The Alleged Hepatotoxicity of Kava (Piper methysticum) as a Case of Ill-Defined Herbal Drug Identity, Lacking Quality Control, and Misguided Regulatory Politics. Planta Med 2015; 81: 1647–1653

Chamomile

  • Adib-Hajbaghery M, Mousavi SN. The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Complement Ther Med. Dec;35:109-114,2017
  • Keefe JR, Mao JJ, Soeller I, Li QS, Amsterdam JD Short-term open- label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder.Dec 15;23(14):1699-1705

Skullcap Leaf

  • R Upton, RH Dayu ,. Skullcap: an American Nervine, Journal of Herbal Medicine 2 (2012) 76-96
  • Brock C, Whitehouse J, Tewfik I, Towell T. American Skullcap (Scutellaria lateriflora): a randomised, double-blind placebo- controlled crossover study of its effects on mood in healthy volunteers. Phytother. Res. 28: 692–698 (2014)

Passion Leaf and Fruit

  • Dhawan K, Dhawan S, Sharma A.Passiflora: a review update. J Ethnopharmacol. Sep;94(1):1-23. 2004
  • Krenn L., Passion Flower ,(Passiflora incarnata L).a reliable herbal sedative.Wien Med Wochenschr.; 152(15-16):404-6.2002
  • Talcott ST, Percival SS, Pittet-Moore J, Celoria C. Phytochemical composition and antioxidant stability of fortified yellow passion fruit (Passifloraedulis). J Agric Food Chem. Feb 12;51(4):935-41.2003

Digest

Gentian Root and Bitters

  • Mennella I, Fogliano V, Ferracane R, Arlorio M, Pattarino F, Vitaglione P.Microencapsulated bitter compounds (from Gentiana lutea reduce daily energy intakes in humans, Br J Nutr. Volume 116, Issue 10, 28 November 2016, pp. 1841-1850
  • Amakura Y, Yoshimura M, Morimoto S, Yoshida T, Tada A, Ito Y, Yamazaki T, Sugimoto N, Akiyama H.Chromatographic Evaluation and Characterization of Components of Gentian Root Extract Used as Food Additives,78 Chem. Pharm. Bull. 64, 78–82 (2016) Vol. 64, No. 1
  • CD Dotson, L Zhang, H Xu, YK Shin, S Vigues, SH. Bitter taste receptors influence glucose homeostasis, Ott- PloS one, 2008 – journals.plos.org
  • Pham H, Hui H, Morvaridi S, Cai J, Zhang S, Tan J, Wu V, Levin N, Knudsen B, Goddard WA 3rd, Pandol SJ, Abrol R.A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells; Biochemical and Biophysical Research Communications, 475 (2016) 295e300
  • Dotson CD, Vigues S, Steinle NI, Munger SD.T1R and T2R receptors: The modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitus, Curr. Opin. Investig. Drugs. 2010 April ; 11(4): 447–454.
  • Nolden A, McGeary JE, Hayes JE. Differential bitterness in capsaicin, pipeline, and ethanol associates with polymorphisms in multiple bitter taste receptor genes. Physical Behav. 2016 Mar 15;156:117-27.

Lemon Verbena

  • Review Aloysia citrodora Paláu (Lemon verbena): A review of phytochemistry and pharmacology Journal of Ethnopharmacology 222 (2018) 34–51

Lemon Balm

    • Carnat, A.P., Canat A, Fraisse D., Lamaison JL, The aromatic and polyphenolic composition of lemon balm ( Melissa officinalis L. subsp. Officinalis) tea. Pharmaceutica Acta Helvetiae 72: (1998) 301- 305.
    • Lin SH, Chou ML, Chen WC, Lai YS, Lu KH, Hao CW, Sheen LY. A medicinal herb, Melissa officinalis L. ameliorates depressive-like behavior of rats in the forced swimming test via regulating the serotonergic neurotransmitter. Journal of Ethnopharmacology Volume 175, 4 December 2015, Pages 266–272
    • Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT. Bioassay- guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother Res. 2009 Aug;23(8):1075-81. doi: 10.1002/ptr.2712.
    • Case J, Ibarra A, Feuillere N, Roller M, Sukkar S. Pilot trial of Melissa officinalis leaf extract in the treatment of volunteers suffering from mild to moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011 December ; 4 (3); 211-218
    • M. Soodi, N. Naghdi, H. Hajimehdipoor, S. Choopani, and E. Sahraei. Memory-improving activity of Melissa officinalis extract in naïve and scopolamine-treated rats Res Pharm Sci. 2014 Mar-Apr; 9(2): 107–114

Lemon Peel

  • Ghasemi K1, Ghasemi Y, Ebrahimzadeh MA. Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues. Pak J Pharm Sci. 2009 Jul;22(3):277-81.

Emerge

Ashwagandha Root

  • Dongre, S., Langade, D., & Bhattacharyya, S. A prospective Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. BioMed research international, 2015.
  • Chandrasekhar, K., Kapoor, J., & Anishetty, S. Randomized double- blind, placebo-controlled study of safety and efficacy of a high- concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. . Indian journal of psychological medicine, 34(3), 255.(2012)
  • Choudhary, D., Bhattacharyya, S., & Joshi, K. Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial . Journal of evidence-based complementary & alternative medicine, 22(1), 96-106(2017)
  • Choudhary, D., Bhattacharyya, S., & Bose, S .Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.. Journal of Dietary Supplements, 1-14. Chicago (2017)
  • Ambiye, V. R., Langade, D., Dongre, S., Aptikar, P., Kulkarni, M., & Dongre, A. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Evidence-Based Complementary and Alternative Medicine, 2013.
  • Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. Journal of the International Society of Sports Nutrition, 12(1), 43.(2015)
  • Sharma, A. K., Basu, I., & Singh, S. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. The Journal of Alternative and Complementary Medicine. Mar;24(3):243-248. (2017)

Holy Basil

  • Jothie Richard E, Illuri R, Bethapudi B, Anandhakumar S, Bhaskar A, Chinampudur Velusami C, Mundkinajeddu D, Agarwal .Anti-stress Activity of Ocimum sanctum: Possible Effects on Hypothalamic- Pituitary-Adrenal Axis. Phytother. Res. 30:805-814 (2016)
  • Jamshidi N, Cohen MM.The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evid. based compl. Altern. med. 2017.
  • Sampath S, Mahapatra SC, Padhi MM, Sharma R, Talwar A. Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study. Indian J. physiol pharmacol. 2015, Jan-Mar;59 (1) 69-75
  • Prakash P, Gupta N. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian J Physiol Pharmacol. Apr;49(2):125-31. 2005

Turmeric Rhizome

  • Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB. Multi targeting by turmeric, the golden spice: From kitchen to clinic. Mol Nutr Food Res. Sep;57(9):1510-28. 2013.
  • Gupta SC, Kismali G, Aggarwal BB.Biofactors.Curcumin, a component of turmeric: from farm to pharmacy. Jan-Feb; 39(1):2-13.2013.
  • Hosseini A, Hosseinzadeh H. Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomed Pharmacother. Mar;99:411-421,2018

Gogi Berry

  • Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 76: 7–19,2010.

Ginger Rhizome

  • Sharifi-Rad M, Varoni EM, Salehi B, Sharifi-Rad J, Matthews KR, Ayatollahi SA, Kobarfard F, Ibrahim SA, Mnayer D, Zakaria ZA, Sharifi- Rad M, Yousaf Z, Iriti M, Basile A, Rigano D. Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy. Molecules. Dec 4;22(12) 2-10. 2017.
  • Langner E, Greifenberg S, Ginger: history and use. Adv Ther. Jan- Feb;15(1):25-44.1998.